Ginger

Ginger is used as herb for a long time in Asia including India.  Also, ginger contains in Chinese herbal formation treated with psychotic disorder for many hundred years.  Bnxiahoupu which consisted of ginger can treat with several metal illnesses including depression, anxiety and schizophrenia [1].  In male mouse study, ginger can attenuate the depression which is associated with serotonin activity as well as ginger also reduce the anxiety in female mice [3], [4]. Moreover, anti-anxiety effect of ginger can equivalent to diazepam [4].  Ginger may increase the activity of5-HT (1A) receptor which results in decreasing the anxiety and depression [5]. 

 

[1] Li, J. M., & Kong, L. D. (2001). [Advances in the study on depressive and anxiety disorders treated with traditional Chinese medicine and herbal drugs]. Zhongguo Zhong Yao Za Zhi, 26(12), 805-807.

[2] Khaki, A., Farnam, A., Rouhani, S., Imantalab, B., &Seery, S. (2013). ANDROGENIC ACTIVITY EVALUATION OF GINGER RHIZOME IN REDUCING DEPRESSION IN THE FORCED SWIMMING TEST OF RATS EXPOSED TO ELECTROMAGNETIC FIELD (EMF) [Article]. INTERNATIONAL JOURNAL OF WOMEN’S HEALTH AND REPRODUCTION SCIENCES, 1(2), 56-63.

[3] S N, H., &Anilakumar, K. (2012). Anxiolytic effects of the extracts of Zingiber officinale in mice. J PharmRes, 5, 219-223.

[4] Adaki, F., Modaresi, M., &Sajjadian, I. (2017). The Effects of Ginger Extract and Diazepam on Anxiety Reduction in Animal Model. Indian Journal of Pharmaceutical Education and Research, 51, s159-s162. https://doi.org/10.5530/ijper.51.3s.4

[5] Nievergelt, A., Huonker, P., Schoop, R., Altmann, K. H., &Gertsch, J. (2010). Identification of serotonin 5-HT1A receptor partial agonists in ginger. Bioorg Med Chem, 18(9), 3345-3351. https://doi.org/10.1016/j.bmc.2010.02.062